Tuesday, January 29, 2013

Rudolf Virchow






Okay, so you might be asking yourself why Rudolf Virchow is today's unlikely science hero.  He is after all, often referred to as "the father of modern pathology" and is credited with a slew of other accolades, like suggesting the cell is the basic unit of life, having a clutch of anatomical/pathological terms bearing his namesake, and helping to found what we today think of as social medicine.  Heck, the Society for Medical Anthropology even gives an award each year in his name to a distinguished article written "in his spirit."  (If you're wondering, the award in 2011 went to Sharon Abramowitz for her article about open mole syndrome in Liberia.  Open mole syndrome, if you're wondering, is a unique "culture-bound disorder," to use Abramowitz's language, that is likened to PTSD or other afflictions of traumatized populations.  But I digress...)  So if it seems like Virchow has done all kinds of amazing things and gotten proper credit for it, then what makes him so unlikely?

There are a few reasons I decided to write about Virchow.  For one, he is barely written about in comparison to other figures in science whose contributions were comparable to Virchow's.  This might have something to do with the fact that Virchow was really a polymath in disciplines that many folks wouldn't normally think of together, but in fact are closely interconnected.  Paul Farmer was quoted in his biography Mountains Beyond Mountains as being deeply influenced by Virchow's marriage of "pathology, social medicine, politics, [and] anthropology."  I love this, because even now bringing these factors together and trying to wrap our collective heads around what this means for health and human rights is very hard to do. Most of us specialize in one field and it's very hard for us to see how inextricable the fate of our field is from the consequences of others, and how we may not be able to solve our own specialized problems in say, public health, without looking at the consequences of a fascist regime that might be limiting access or worse.  

This is in fact the central tenet of what we call social medicine.  It's a very well known concept- to consider how socioeconomics make us healthier or sicker, and in theory seems like a cut and dry concept- make people's social and economic lives better, and they will be healthier.  What's great about Virchow is that he was a specialist in many fields, and so was able to make astute observations, that were both groundbreaking at the time, and also led to his own pragmatic solutions to improve health outcomes in unprecedented ways and weren't limited by a lack of knowledge in disparate areas. The best known story about this is when Virchow was sent to the Silesia region of Europe (that's now Poland, Czech Republic and a little Germany for the rest of us) to address an epidemic of relapsing fever.  To the dismay of the German government, Virchow did not have a scientific answer for them, but instead blamed the oppressive politics and poverty imposed on the region for the epidemic, which was revolutionary at the time.

Despite being extremely prolific himself- he penned likely more than two thousand papers in his lifetime- very little was written about him.  It seems like if you're interested in learning more about Virchow, this Ackerknecht book and this book by B.A. Boyd are the best options.  I also found what appears to be a book published just last year that I can't speak for but appears to be written in much the same spirit of this blog so might be more accessible than the other dusty old tomes (It could also be bad.  Who knows.) 

Since Virchow was such a renaissance man, he is credited with a slew of one-off terms and concepts.  But what is kind of interesting is that many of Virchow's most "famous" discoveries were made simultaneously with other researchers.  This could speak in part to the collaborative nature of science and discovery, but it could also speak to Virchow being kind of a ham and looking for credit.  For instance, you could reasonably argue that Theodor Schwann actually is the father of cell theory along with Schleiden, and Virchow just had better marketing with his Omnis cellula e cellula.  (In fact, Virchow didn't even really believe in cell division until he heard a really great argument from Robert Remak, and then he published Remak's work as his own!  Maybe this entry should be about Remak!  That's a really shady move, Rudolf.)  Or that Virchow's Node is really just Troisier's Sign?  Or Virchow-Robin Spaces should be Robin-Virchow?  Or Virchow-Seckel Syndrome should be Seckel-Virchow?  Though the Virchow Method of Autopsy is fully his own, and is in large part still in use today.  I am actually very amused by all of this, and I think I might plan to read Virchow's Eulogies before the end of this Winter to honor his spirit of collaboration :)

Some other fun Virchow facts:
-Bismarck once challenged Rudolf to a duel because he was so over being voiciferously criticized by the medical anthropologist.  Legend has it that as Virchow was to select the weapons, he selected two sausages, one of which was laced with Trichinella.  And the elder statesmen chickened out.
-Virchow published the "Virchow Archives" for much of his life, supporting groundbreaking research and writing that went against the the prevailing romantic speculation of German medicine at the time.
-Virchow had no qualms mixing politics and medicine and saw political action as a road to health equity.  He was a member of the Reichstag and co-founder of the German Progress Party. 


Friday, January 25, 2013

Jean Baptiste Lamarck

I'm no PhD, but in my short time as a post-bacc I've found that I'm especially interested in the progression of scientific history- how theories are proposed, heralded, discredited and discarded.  Much like pop culture interestingly, the scientific community will fixate on one figure. Despite the breadth of their contribution, or lack of, the mythology of their theories and work gets distorted over time as folks add and subtract to them. Certain people will not get the credit they deserve for their work, or alternately too much credit for work they maybe didn't do, but became central because of the discoveries of others.

I think it's also interesting how little time is spent in science classes looking at where these theories are coming from- historically, culturally, contextually.  I think it's most likely in the interest of time since you have only so many lectures to squeeze in all the practical knowledge that is required for the course- but I think it's helpful to think about where this information comes from, so we can be critical about it, and maybe make more informed decisions moving forward with our own work as fledgling contributors to the scientific community.

That being said, today's Unlikely Science Hero is Jean-Batiste Lamarck.  People seem to talk a lot of smack about Lamarck, with the exception of my brilliant genetics professor.  When I was recently studying for the MCAT last Summer, Lamarck was even listed in the official AMCAS study guide as the right answer to "wrong evolution."  After a quick check on Wikipedia, which I feel like is the most likely first source of information for people in general, and so in many ways reflects the greater knowledge of people about a subject, Lamarck's theory is said to "reflect folk wisdom of the time," which is both true and untrue.  While most people recognize that Lamarck was really the first one to propose a unified theory of evolution that linked changes in the demands of environment to changes in the phenotype of organisms, people also kind of write him off as a silly goose, that "use and disuse" is not a useful framework of evolution because you can't inherit a change in your parents unless it's genetically encoded.

But now we've discovered this super cool new phenomenon called epigenetics, where gene expression can be changed from generation to generation by mechanisms that AREN'T related to the underlying DNA sequence.  Epigenetics is so new (the term was coined in 1942, but it's only recently gaining momentum with research) that as I type this, Blogger doesn't even recognize the word!  It also means that maybe Lamarck wasn't as folksy as people thought he was, and his ideas were actually pretty revolutionary. 

In popular culture, there was recently a very nicely done Radiolab which among other interesting stories about environment and inheritance (including an excellently entertaining tale of a true charlatan that ends in tragedy) told the story of a recently released study between scientists at McGill and Columbia about epigenetics in action in the minds of mother rats.

Even just today, the New York Times printed this article about mutations in gene control regions  as opposed to genes themselves as an underlying cause for some cancers.  Gene control regions that have been directly mutated by UV light- the environment.

Was Lamarck right that the baby giraffe's neck would be longer because it's mother had reached higher and higher for leaves, stretching herself?  No.  But did he have some brilliant insight into the possible ways our environment has the potential to act directly on us?  Perhaps!

Some other cool things Lamarck has done include: 

Earning marks for bravery in the Pomeranian War (Pomeranian War!  That is a funny mental picture to me..)

Coined the term invertebrates and went on to have many species named in his honor, like the honey bee! (Apis mellifera lamarckii)

Wrote a seven volume work on invertebrates that is still useful today

So before you go throwing a party for Darwin, remember that Lamarck came first, and that much of what people consider Darwinian today is an amalgamation of Lamarckism, Darwinism, and a lot of new -isms that have accumulated onto Darwin as the decades have passed.


Rosalind Franklin

Before I even begin, I want to link to this thoughtful blog entry on the subject of Rosalind Franklin.  Since my blog is just a contribution from a novice and is meant for a more general audience, I think this blog entry, and subsequently the Maddox biography will give you a more nuanced idea of the situation than I can.  But, I have totally fallen in love with Rosalind Franklin.  It probably has a lot to do with the fact that my background is in photography, and it was Franklin's x-ray crystallography that made the discovery of the structure of DNA possible for Watson and Crick.

It wasn't until after encouragement from my really great organic chemistry professor to read Watson's memoir The Double Helix that I really got interested in Franklin's life, because regardless of whether or not you agree that Franklin should have been included in the Nobel Prize for the discovery (I say yes) she was really treated unfairly in the book by Watson.  Whether or not Franklin received the accolades she deserved based on her gender alone (I say no again, and agree with the prevailing historical view that her personal differences with Maurice Wilkins were a two way street) they did after all use her photographs without her permission, gave her the shaft in a bestselling memoir, and then only added the epilogue rescinding his awful portrayal of her after she died.  It's all fine and good that she, Watson and Crick all ended up to be close friends, but I don't think Franklin will ever be undeserving of any efforts folks make from here on out to point out what an incredible and brilliant scientist she was.

Some other amazing things Rosalind Franklin accomplished in her life include:
Received Second Class Honours at Cambridge before they were even awarding any B.A.s or M.A.s to women. (Cambridge eventually went back and awarded these fantastic women degrees after the fact)
Made important contributions studying coal while earning her PhD.
Was a prolific writer and researcher and published oodles of work, especially on the tobacco mosaic virus and the polio virus.
 
Franklin has been awarded numerous accolades posthumously, so let's give her another one on this humble blog.  <3